Dynamic interactions between cells and extracellular matrix (ECM) through integrins influence most cellular functions. Normal cells, but even more, tumor cells are subjected to different forms of ...

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

Dr. Hynes coined the term “integrin” for these wonderfully complicated molecules that “integrate” the extracellular matrix with the intracellular environment (the cytoskeleton, in particular).

Cell-extracellular matrix adhesions are formed at two types of integrin-dependent junction: focal adhesions and hemidesmosomes. ... The extracellular matrix proteins fibrin, ...

News on integrin. Date. 6 hours 12 hours 1 day 3 days all. Rank. Last day 1 week 1 month all. ... but also to extracellular structures, such as collagen fibers of the connective tissue and the skin.

EMMPRIN is known for its ability to promote the invasiveness of tumor cells by stimulating the extracellular matrix (ECM) degradation, and to stimulate tumor angiogenesis. In tumor cells EMMPRIN ...

Cy-cles of integrin-mediated "gripping and let loose" allow cells to move in the protein meshwork of the extracellular matrix like a sailor climbs in the ship's rigging. Integrins consist of two ...

Integrin binding to ECM is crucial for cell anchorage to the surrounding matrix, spreading, migration, and further activation of intracellular signaling pathways.

Some of the major conserved molecular processes involve TGF-β, PDGF, CTGF, vasoactive compounds (endothelin-1 and angiotensin II), and integrin–extracellular matrix signaling pathways.

More information: Tatsuki Isogai et al, Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202404064 ...

Cell "hands," syndecan-4/integrin complexes, reach across the cell membrane, "feel" external mechanical cues, and trigger molecular pathways that contribute to cancer ...