Integrin activation unbends the molecule either by ligand binding or by effects on the cytoplasmic domains which straightens and separates the legs of the molecule. ... But while researchers have made ...

Oncology, a team of expert scientists specializing in immuno-oncology extensively outlined the complexities involved in the ...

Their work to take apart and re-build the signaling pathway that regulates activation of the body's most abundant platelet receptor, an integrin called glycoprotein (GP) IIb-IIIa, provides a ...

Nader, D. and Kerrigan, S. (2022) "Vascular dysregulation following SARS-CoV-2 infection involves integrin signalling through a VE-Cadherin mediated pathway". bioRxiv . doi : 10.1101/2022.03.15 ...

The new study suggests that ARVC-causing mutations in a desmosomal protein result in the activation of a signaling pathway, which in turn leads to the loss of the integrin beta 1D protein.

Endocytic pathway proteins Rab5a and Rablla were used as vesicle markers to characterize the movement of integrins on the pathway. The 786-O cell line comes from a patient that had VHL disease. 786-O ...

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...