The interleukin-6 receptor (IL-6R) is the receptor that IL-6 binds to in order to initiate the body’s responses to inflammation and infection.

Fig.1 Interleukin-6 Classical and Trans-Signaling.[26] Diseases Mediated by IL-6 and Its Clinical Significance. Interleukin 6 (IL-6) assumes a pivotal role in immune regulation, inflammatory responses ...

Interleukin-6 (IL-6) is a crucial component of both the immune and inflammatory systems within the body. ... IL-6 binds to its receptor IL-6 R, in both transmembrane and soluble forms, ...

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet. 2008;371:987-997.

Blockade of interleukin-6 (IL-6) or its receptor (IL-6R) is effective in preventing the progression of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In the ...

Tocilizumab, an interleukin-6 receptor inhibitor, improved myocardial salvage in patients with first-time acute STEMI compared with placebo, according to the ASSAIL-MI trial presented at the ...

Interleukin 6 receptor (IL-6r) inhibition is a promising approach for the treatment of calcium pyrophosphate deposition disease (CPPD), although no prospective studies have been conducted to date.

Sarilumab treatment with a rapid glucocorticoid taper in relapsing polymyalgia rheumatica shows greater improvements in ...

During the pandemic, healthcare professionals have been using immune-modifying drugs called interleukin-6 (IL-6) receptor inhibitors “off label” in an attempt to prevent this from happening.

Background: Castleman Disease (CD) comprises a clinically and histologically heterogeneous group of rare lymphoproliferative disorders and presents either with localized (unicentric, UCD) or ...

Sarilumab, a human monoclonal antibody, binds interleukin-6 receptor α and efficiently blocks the interleukin-6 pathway. We performed the Sarilumab in Patients with Polymyalgia Rheumatica ...