O nce clinical suspicion has been established for primary biliary cholangitis (PBC), the " serologic hallmark " of the ...

Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. Whether elafibranor ...

Bile duct destruction, interlobular duct loss, proliferation of bile ducts, portal tract and interface inflammation, and portal fibrosis: 3: ...

Liver core biopsy revealed moderate centrilobular cholestasis with intrahepatocytic and intracanalicular bile deposits, as well as a loss of true interlobular bile ducts in 70-80% of portal tracts ...

Purpose: Alagille syndrome is an autosomal dominant condition characterized by a paucity of interlobular bile ducts and chronic cholestasis, cardiac disease, skeletal abnormalities, ocular ...

Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment bile ducts and area bile ducts), small bile duct group (septal bile ducts and interlobular bile ducts ...

The acquired or perinatal form of biliary atresia is a Th1 fibro-inflammatory disease affecting both the extrahepatic and intrahepatic bile ducts. Osteopontin (OPN) is a Th1 cytokine implicated in ...

Defective small interlobular bile ducts characterize CHF. On the other hand, CD is characterized by defective large intrahepatic bile ducts, and CS is the combination of CHF and CD. 14 ASC, ...

Bile ducts act as the liver's waste disposal system, and malfunctioning bile ducts are behind a third of adult and 70 per cent of children's liver transplantations, with no alternative treatments.

The interlobular septa are thickened by a proliferation of myofibroblasts and infiltrated by lymphocytes and plasma cells. Figure 1. ... the gallbladder, bile ducts, kidney, ...