O nce clinical suspicion has been established for primary biliary cholangitis (PBC), the " serologic hallmark " of the ...

Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. Whether elafibranor, ...

Chronic obstruction of the common bile duct may cause hepatic fibrosis and secondary biliary cirrhosis. We studied liver-biopsy specimens from 11 patients with chronic stenosis of the common bile d ...

Histology The histologic hallmark of PBC is biliary epithelial cell destruction leading to the eventual loss of small interlobular bile ducts.

Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment bile ducts and area bile ducts), small bile duct group (septal bile ducts and interlobular bile ducts ...

Liver core biopsy revealed moderate centrilobular cholestasis with intrahepatocytic and intracanalicular bile deposits, as well as a loss of true interlobular bile ducts in 70-80% of portal tracts ...

OPN appears to be localized predominantly in interlobular biliary epithelium and bile within duct structures. Its increased expression in biliary atresia coincides with proliferation of biliary ...

Purpose: Alagille syndrome is an autosomal dominant condition characterized by a paucity of interlobular bile ducts and chronic cholestasis, cardiac disease, skeletal abnormalities, ocular ...

Chronic cholestasis, defined as the impairment of bile acid formation and/or flow persisting for more than six months, encompasses a broad spectrum of hepatobiliary disorders, both heritable and ...

Scientists have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first ...