And yes, the show is still led by original cast members Chandra Wilson, James Pickens Jr., and—occasionally—Ellen Pompeo. But while the series has certainly proved its longevity, a lot of changes have occurred over the years.

Washington's firing over the use of a homophobic slur made the "bubble of joy" from the show's success "burst so early," Rhimes saidShonda Rhimes thought that the Isaiah Washington scandal that surrounded Grey's Anatomy nearly two decades ago would be the show's final straw.

Grey's Anatomy creator Shonda Rhimes has spoken about a moment on set involving Isaiah Washington nearly 'killed the show'.