Researchers have new insights into the citric acid cycle: Certain bacteria can use this central metabolic pathway 'backwards', but to do so they must have very high concentrations of the enzyme ...

Journal reference: Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2R,3S)-Isocitric Acid by Fermentation of Sunflower Oil. Angewandte Chemie International Edition. doi: 10.1002 ...

The citric acid cycle begins with the reaction that combines the two-carbon acetyl CoA with a four-carbon oxaloacetic acid to produce the six-carbon molecule citrate.

Title: Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2R,3S)-Isocitric Acid by Fermentation of Sunflower Oil Angewandte Chemie International Edition, doi: 10.1002/anie.200705000 ...

In industry and domestic applications, citric acid is a chelating and buffering agent in many cleaning products and a starting material for synthesizing citrate esters, itaconic acid, ...