The KEAP1 gene mutation allows them to maintain a delicate balance between energy and protection against cellular damage. The study compared the KEAP1 gene in 196 mammalian species, revealing an ...

NRF2/KEAP1 is also associated with metabolism and exists in all vertebrate animals. NRF2, a protein, prevents damage from reactive oxygen species and enhances the production of cellular energy. KEAP1, ...

Researchers studying the DNA of nearly 200 mammal species noticed something strange in the genome of horses: a mutation in a gene that should have shut down a key cellular process.

image: International team identifies a new regulatory pathway in bladder cancer view more . Credit: Insilico Medicine. August 20th, 2020, Hong Kong - Researchers from Johns Hopkins University in ...

Targeted therapies are currently available for about one-third of people with lung adenocarcinoma, the most common kind of lung cancer. These drugs inhibit cancer cells by thwarting the molecular ...

The POSEIDON exploratory analysis that dovetailed into the TRITON investigation saw STK11 mutations in 14% of the patients with nonsquamous NSCLC (n = 87), KEAP1 mutations in 6% (n = 51), and KRAS ...

These mutations included those in tumor suppressor genes STK11, KEAP1 and ARID1A, which researchers assessed in baseline plasma samples from 1,003 patients, representing 89.7% of the intention-to ...

In addition, we know that patients with lung cancers that harbor mutations in the NRF2/KEAP1 pathway typically have poorer outcomes than those whose tumors do not have these mutations,” said ...

Lung cancers that possess KRAS and KEAP1 mutations account for about 10% of diagnosed cases, estimates Thales Papagiannakopoulos, a co-author of the study and assistant pathology professor at NYU ...

About 20% of adenocarcinomas of the lung are marked by alterations in a cell signaling pathway called KEAP1/NRF2. | About 20% of adenocarcinomas of the lung are marked by alterations in a cell ...