Tissue microarray was used to detect the expression of an autophagy marker, LC3B in BCa patients (normal/hyperplasia=8; grade-I=15, grade-II=84, and grade-III=27) and BCa cell lines.

Conversely, treatment with rapamycin, an inducer of autophagy, increased LC3B-II levels and enhanced PARK7 secretion, indicating that autophagy induction was essential for PARK7 secretion.

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging , 2024; DOI: 10.1038/s43587-023-00548-1 ...

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.