In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, ...

For the ligand gating in HCN2 channels we recently described a complex Markov model with pronounced hysteresis, in which ligand binding proceeds preferentially along the closed states, whereas ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

In addition to the expertise in ion channel drug discovery, the expertise that Ligand is acquiring from Icagen in medicinal chemistry, in silico and computational chemistry will complement and ...

Ligand-gated ion channels (LGICs) represent an important class of drug targets that play a critical role in the function of the central nervous system. Compounds acting on ligand-gated channels ...

Understanding protein–ligand interactions is fundamental to molecular biology and biochemistry. These interactions are at the heart of many cellular processes, from enzyme catalysis to signal ...

The flow of ions through cation-selective members of the pentameric ligand-gated ion channel family is inhibited by a structurally diverse class of molecules that bind to the transmembrane pore in ...

SAN DIEGO -- (BUSINESS WIRE)-- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announces the completion of its acquisition of the core assets of Icagen’s North Carolina operations. As ...

The ligand is a descendant of cyclopentadienyl (Cp), found in the iconic sandwich complex, ferrocene. One common variant of this ligand is known as Cp*, in which each of the five cyclopentadienyl ...

Simplified redesign of proteins to improve ligand binding Date: January 21, 2025 Source: University of Alabama at Birmingham Summary: The ability to alter proteins to refine control over binding ...

Figure 1. Promiscuous modulation of ligand-gated ion channels. The four members of the cys-loop family of ligand gated ion channels are shown as black nodes.