We investigated effects of antimanic treatments on specific aspects of mania, prediction of response, and the existence of naturalistic subgroups of patients with different treatment response in ...

Lithium (Li) was first used to treat manic episodes in the late 1940s, but it was not approved for clinical use in the US until 1970. Despite Li's marked antimanic activity, response to the drug ...

Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial. Am J Psychiatry . 2005;162:1281-1290. 58.

Lithium has been the mainstay of treatment for decades, ... Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials. Neuropsychopharmacology. 2011;36:375-389.