The targeted knockout of the c-myc gene from rat fibroblasts leads to a stable defect in cell proliferation. We used complex cDNA libraries expressed from retroviral vectors and an efficient ...

Researchers have developed a peptide that targets a protein implicated in 75% of human cancers and found that it slowed the proliferation of cancer cells in the lab. It’s the first step towards ...

We first infected cells with retroviruses encoding c-Myc, or with control empty vectors, and we scored the ability of c-Myc to enhance cell proliferation. As expected, wild-type MEFs responded to ...

On the other hand, employing a chemical genetic approach, it was recently reported that specific small molecule inhibition of CDK2 kinase activity diminished cell cycle progression in nontransformed ...

We identified USP17 as a novel deubiquitinating enzyme regulating c-Myc levels to control cell proliferation. Overexpression of USP17 stabilized the c-Myc protein by promoting its deubiquitination ...

Functional analysis revealed that KDM5A cooperates with MYC, ... "Our research has elucidated part of the mechanism of myeloma cell proliferation mediated by histone modification regulation, ...

Notably, a small molecule inhibitor of MYC-MAX heterodimerization used on human B-cell lymphoma and several other cancer cell lines showed a decrease in MYC protein expression, reduced proliferation ...

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that is estimated to drive the development of almost half a million new cancer cases in ...

Researchers have uncovered a crucial enzyme responsible for a specific chemical modification linked to the growth of a severe subtype of acute myeloid ...

Conclusions: Our preliminary data have implicated MYC as a potential critical target for the cytotoxic effects of statins on prostate cancer cells. The prevalence of MYC overexpression in human ...

MYC genes and their proteins play a central role in the emergence and development of almost all cancers. They drive the uncontrolled growth and altered metabolism of tumor cells.