Instead, MYC can be deregulated through chromosomal translocation, gene amplification, and post-translational modifications, all of which result in elevated MYC protein expression and deregulated ...

Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not ...

Oct. 5, 2021 — Researchers identified a small RNA molecule called miR-766-5p that reduces expression of MYC, a critical cancer-promoting gene. This microRNA reduces levels of proteins CBP and ...

Mice with one rather than the normal two copies of the gene Myc ... Reduced Expression of MYC Increases Longevity and Enhances Healthspan. Cell, 2015; DOI: 10.1016/j.cell.2014.12.016; ...

JQ1 binds to a bromodomain protein called BRD4, which is involved in the activation of RNA polymerase II regulating the expression of c-Myc, to inhibit this stream strongly.

The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Scientists at The Wistar Institute have now shown that MYC activates a gene called MTA1, which has been ...

The c-myc gene is commonly activated in a variety of human tumors. As a new report in the October 1 issue of Genes & Development shows, scientists are gaining a better understanding as to why. Dr ...

Finally, the authors sought to understand how MLX works with other MYC network proteins to regulate germ cell gene expression. Chromatin immunoprecipitation showed that MLX and MAX, MYC’s obligate ...

Scientists have long known that in tumor cells, elevated levels of MYC’s protein product, c-Myc, are associated with poor clinical outcomes, including increased rates of metastasis, recurrence, and ...