Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail the growth of several cancer types. A review paper published last year in European ...

That's because mis-regulation of Myc proteins is a hallmark of cancer and N-Myc plays a key role in childhood brain cancers. "Because Aurora-A stabilizes N-Myc against degradation, inhibiting the ...

When Maralice Conacci-Sorrell joined Bob Eisenman’s lab at the Fred Hutchinson Cancer Research Center in Seattle, Washington, she started studying the transcription factor and major oncogene protein, ...

What additional lessons can be learned? Is MYC stability altered at specific subcellular locales, or when in partnership with certain DNA, RNA or protein molecules, or as a mechanism to regulate ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

Sarki Abdulkadir, MD, PhD, John T. Grayhack Professor of Urologic Research and director of the Center for Urologic Oncology at the Feinberg School of Medicine For decades, researchers have known that ...

BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

RNA sequencing expression analyses indicated that Parabilis’s ERG degrader downregulated Myc target genes. Parabilis’s ERG degrader uses Helicon technology to bind directly to the ERG protein ...

The protein component of HAMLET is α-lactalbumin ... Sensitivity to HAMLET is defined by oncogene expression including Ras and c-Myc and by glycolytic enzymes. Cellular targets are located ...

Parabilis Medicines (formerly Fog Pharmaceuticals), a clinical-stage biopharmaceutical company committed to creating ...