A macule is simply the medical term for a small area of discolored skin, including freckles and age spots. A macule is a flat, distinct, discolored area of skin less than 1 centimeter (cm) wide ...

In vivo reflectance confocal microscopy can be used to distinguish between benign melanotic macules and lip melanoma, according to study results recently published in JAMA Dermatology. Researchers ...

The medical team noted dark macules on both shins and tight, fluid-filled blisters on the front of his right lower leg, the top of his foot, and toes.