These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was ...

AT8 immunoreactivity was not seen in western blots of homogenates from Tg12099 hemizygotes up to 18 months of age. ... Tg12099; Mapt-/-rats developed tau pathology—including neurofibrillary ...

They mutated mice genes associated with frontotemporal dementia, specifically two lines of the MAPT gene. Subsequently, they looked at how tau hyperphosphorylation influenced pathological changes ...

The study was published in the Alzheimer's & Dementia journal under the title "The TAU isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and ...

Kathryn Bowles started her lab at the UK Dementia Research Institute at the University of Edinburgh (UK) in September 2022. Her research primarily focuses on tauopathies, with an interest in anything ...

Aquinnah Pharmaceuticals Inc. has identified new TAR DNA-binding protein 43 (TARDBP; TDP-43) aggregation and microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be ...

(2025) The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction. Alzheimer's & Dementia. doi.org ...