The effects of microtubule polymerization on liposome-mediated gene transfection were investigated by confocal laser scanning microscopy in target living cells. Both nocodazole and taxol ...

In a living cell their growing ends constantly elongate and retreat in a thrashing frenzy of polymerization and depolymerization, ... GTP, controls activity at the growing end of the microtubule.

Using nocodazole, a synthetic tubulin-binding agent that disrupts microtubule polymerization, they showed that nocodazole-induced loss of microtubule polymerization disrupted basal body positioning ...

The ability of kinetochores (KTs) to maintain stable attachments to dynamic microtubule structures (‘straight’ during microtubule polymerization and ‘curved’ during microtubule ...

Visualizing 'unfurling' microtubule growth Date: November 13, 2018 Source: University of California - Davis Summary: Living cells depend absolutely on microtubules that form a scaffolding for ...

Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, which are the dynamic ends ...

To test the hypothesis that microtubule disruption might affect how expressed gene transcripts get translated into proteins, Lee first induced cell cycle arrest while also disrupting microtubules by ...

Process Component Function Recommended Products; Microtubule nucleation: γ-tubulin: Forms part of the microtubule organizing centers (MTOCs), and facilitates tubulin dimer polymerization.

Below: Model of CAMSAP2-mediated microtubule polymerization/network formation. The following phenomena were observed: tubulin connecting vertically, curling to form ring shapes ...

Microtubule-targeting agents impact microtubule dynamics to induce mitotic arrest and tumor cell death. Tubulin is therefore a relevant target for the discovery of new agents acting as tumor ...

Cells with defects in tubulin polymerization die. Microtubule fibers are hollow rods made of much smaller tubulin subunits that spontaneously assemble at one end of the rod, but exactly how they ...