When Mitochondria Don't Get Moving, Motor Neuron Disease May Develop Sep 19, 2014 (SALT LAKE CITY)—A new study by researchers at the University of Utah School of Medicine sheds light on a longstanding ...

Mitochondria may be actively recruited to presynapses to supply energy, buffer calcium and, potentially, fulfil other functions. In this Review, Devine and Kittler examine the importance of this ...

Mitochondria are organelles ... which can cause apoptosis, or cell death. For mitochondria to perform its ... To study how the movement of mitochondria is related to motor neuron disease, ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...

In studying nerve cell death from these and other conditions, scientists around the world had noted that some markers of apoptosis, generically known as "programmed cell death," were present, but ...

For the first time, using a mouse model of Alzheimer's disease, scientists have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain.

Nec-1 specifically prevented the mitochondrial dysfunction, loss of cellular ATP content and plasma membrane integrity, and late-stage ... what are the triggers for necroptosis and what is its ...

Mitochondria lacking the candidate protein VAP showed a reduction in length after photoactivation, suggesting destabilization of the dendritic mitochondrial compartment. The team next explored the ...

Thus, they reflect Bax activity in mitochondria during apoptosis, demonstrating how apoptotic Bcl-2 proteins such as Bax remodel the supramolecular architecture of the MOM shell to further drive ...

Instead, their structure and function vary depending on their location within the neuron. Mitochondria in the farthest reaches of the dendrites of neurons—at the outermost synaptic input ...

“We observed a significant loss of the mitochondrial protein COXIV in demyelinated Purkinje cells, suggesting that mitochondrial impairment contributes directly to cell death and cerebellar damage.” ...