A new study sheds light on how autophagy, the body’s process for removing damaged cell parts, when impaired, can play a role in causing heart failure. The research team led by Dr. E. Dale Abel ...

A new study sheds light on how autophagy, the body's process for removing damaged cell parts, when impaired, can play a role in causing heart failure. The research team led by Dr. E. Dale Abel ...

The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve ... including those that target mitochondrial bioenergetics and autophagy.

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science , 2015; 350 (6265): aad0116 DOI: 10.1126/science.aad0116 Cite This Page : ...

Failure of mitochondrial quality control causes heart disease. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 10 / 191016131220.htm ...

One explanation for why heart failure develops goes all the way to the miniscule organelles inside individual cells. From Georgia State University, researchers from a new study show how one ...

The heart has an unrelenting need for energy and thus any mitochondrial dysfunction will impair the heart’s ability to pump blood. If we could target compounds to enhance KLF4 in specific ...

Using a drug called AD-9308 on samples of human heart tissue, the researchers were able to restore Dicer activity and reverse the effect of heart failure, improving cardiac function in rodent models.

Investigations in Japan have uncovered some molecular mechanisms behind mitochondrial dysfunction in chronic heart failure. Chronic heart failure causes the cell's powerhouses to dysfunction, in ...

The discovery could help scientists design new therapeutic agents to combat calcium overload of mitochondria in conditions such as heart failure and Alzheimer's disease. Mitochondrial calcium ...

Heart failure stands as a leading cause of mortality worldwide, ... "The strides made in mitochondrial activation bring us closer to a future where cardiac therapy is not just a treatment but a ...