Dynamics of mitochondria in living cells: fission and fusion maintain homeostasis Mitochondria are dynamic organelles that can change in number and morphology within a cell during development, the ...

Dysregulation of mitochondrial dynamics has been linked to impaired development and cancer progression, including breast cancer metastasis.

This knowledge will increase understanding of the dynamic mitochondrial functions in cells and in particular, the pathogenesis of mitochondrial-related neurodegenerative diseases.

Mitochondrial dynamics are pivotal in breast cancer metastasis, influencing metabolic flexibility, stemness, and therapy resistance. Targeting fission, fusion, and mitophagy offers a ...

To better understand the potential roles of Bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analysis of mitochondria in animals that either lose or have increased ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and ...

Shapeshifting mitochondria continually fuse and divide, but precisely how those dynamics influence metastatic progression has intrigued scientists. In the work published in Science Advances, the ...

The central goal of research in the Mears Lab is to investigate proteins that regulate mitochondrial dynamics. Mitochondrial dynamics has recently come to the forefront as a therapeutic target in ...

Results provide new insights for apoptosis research, and could lead to opportunities to explore Bax and its relatives as interesting targets in cancer therapy.