Mitochondria provide the lion’s share of energy that cells need to function normally, so genetic defects in mitochondria can cause severe diseases that can be devastating if not caught and treated ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these ...

“Mitochondrial dysfunction probably results from other problems in the mitochondria, ... a symptom of biological aging. They compared mitochondrial function in two groups of people over 60 ...

Mitochondria dysfunction, oxidative stress and aging Mitochondria generate energy needed for supporting cellular functions. Therefore, normal mitochondrial function is critically important for a ...

Disturbances in the function of mitochondrial DNA can accelerate the aging process in ways that are different than previously thought, according to a new Finnish study published in Nature Metabolism.

Researchers at the University of Cologne found that mitochondrial dysfunction leads to early skeletal aging by disrupting cartilage metabolism. The study identified maladaptive metabolic shifts, ...

New research published in Nature Communications into hidden mutations in mitochondrial DNA has uncovered how high mutational levels coincide with later life and link to aging markers.

More information: Silvia Vaena et al, Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response, Cell Reports (2021). DOI: 10.1016/j.celrep.2021. ...

During normal disease-free aging, there is also an accumulation of insoluble proteins. ... "Mitochondria have a strong link with aging. They've got a strong link with amyloid beta," he said.

More information: Qiudan Luo et al, The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer's disease, Aging Research (2024). DOI: 10.26599/AGR.2023.9340020 ...

The Aging Cell paper links, for the first time, mitochondrial dysfunction to the shortening of telomeres, a key biomarker of premature aging. “Telomeres are specialized DNA sequences that act as caps ...