Mitochondrial Dysfunction–Induced Apoptosis in Breast Carcinoma Cells Through pH-Dependent Intracellular Quercetin NDDS of PVPylated-TiO 2 NPs. JGO 4 , 215s-215s (2018). DOI: 10.1200/jgo.18.86800 ...

The review highlights the role of Bcl-2 family proteins, such as BAX and BAK, which facilitate mitochondrial membrane permeabilization during apoptosis. Endoplasmic reticulum stress and ...

Several neurodegenerative diseases (e.g., Alzheimer’s disease-AD) have been associated with different mechanisms linked to mitochondrial dysfunction, such as apoptosis and ROS generation.

BAKX Therapeutics is a New York and Boston based company focused on developing safer, more effective therapeutics that fully realize the potential of the mitochondrial apoptosis pathways.