The molecular structure of the MmpL4 efflux pump in Mycobacterium tuberculosis reveals a coiled-coil domain essential for exporting the siderophore mycobactin and for bedaquiline resistance.

The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography. But more ...

During protein synthesis, several ribosomes bind to a single messenger RNA (mRNA) forming large macromolecular assemblies called polyribosomes. Here we report the detailed molecular structure of a ...