The findings revealed that anti-nephrin autoantibodies were prevalent in 69% of adults with MCD and 90% of children with INS who had not been treated with immunosuppressive drugs.

Nephrin is a major component of the glomerular filtration barrier. Mutations in the nephrin gene (NPHS1) are responsible for congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin was ...

Using a hybrid technique, researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalised treatment approaches.

Findings of minimal change disease in adults and children with autoantibodies targeting nephrin supports prior research demonstrated in animal models.“Failure of the glomerular filtration ...

References: Huber TB, et al. Autoantibodies targeting nephrin in podocytopathies.Presented at ERA Congress, May 23-26, Stockholm, Sweden. LBA. Hengel FE, Dehde S ...

Scientists in Japan have found a "skeleton key" for congenital kidney disease research. Using iPS cells generated from the skin cells of a patient with a nephrin mutation, Kumamoto University ...

The findings revealed that anti-nephrin autoantibodies were prevalent in 69 per cent of adults with MCD and 90 per cent of children with INS who had not been treated with immunosuppressive drugs.

PAX8 and NEPHRIN co-expressing cells were detected within the glomerulus of a nephrotic rat during LS-FMD. Credit. CHLA, GOFARR Lab. Usage Restrictions. none. License. Original content.

NPHS1 is the gene responsible for encoding nephrin. Nephrin is the most important protein for the formation of the renal glomerulus slit diaphragm, which acts as a barrier against urinary proteins.