For the motors to transport mitochondria, enzymes known as Mitochondrial Rho (Miro1) GTPases act to attach mitochondria to the motors. To study how the movement of mitochondria is related to motor ...

This mitochondrial gene replacement technology allows for creation of in vitro stem cell-based models useful for understanding neuronal development and treatment of neurodegenerative disorders.

Mitochondria are organelles ... To study how the movement of mitochondria is related to motor neuron disease, Nguyen developed two mouse models in which the gene that makes Miro1 was knocked out.

With new gene activation tools developed by this group, neuron-enriched mitochondrial proteins could be activated at an early stage of the reprogramming process of astrocytes to neurons.

To determine whether any of these proteins tether mitochondria to actin, the team knocked down each candidate gene individually and visualized changes in the mitochondria-actin interaction using a GFP ...

Now, a study published in the journal Science Signaling has identified, for the first time, a molecular complex that affects transport of mitochondria within neurons and regulates neuronal death ...

Columbia neuroscientists have discovered why mitochondria, tiny power generators that keep our cells healthy, are often strangely shaped inside the brain. Skip to content. Menu.

Researchers report that eight healthy babies were born with the help of an experimental technique that uses DNA from three ...

"This suggests that mitochondrial diversity isn't just a biological quirk," said Farris. "It's a fundamental feature that allows different parts of the same neuron to function in distinct ways." ...

“I’ve been a mitochondrial biologist for 25 years, ... and see if mitochondrial gene editing works in animals. “This is just the first step,” says Shoukhrat Mitalipov, ...