Previous work by the team had shown that the NOTCH signaling pathway played a central role in differentiation, which is essential for an effective immune response by CD8 + T cells.

Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. Notch pathway maintains stem cell populations and regulates ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling. The canonical NOTCH pathway maintains resistant cell populations, while ...

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to resistance by regulating cell survival, apoptosis, and the tumor ...

The Notch signaling pathway is of considerable interest to those studying Alzheimer's disease because the Notch receptor and the amyloid-β precursor protein ... re-expression of a developmental ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

Liming Li, Xiaqing Liu, Mingguang Zhao, Peng Guo, Haifeng Zhang, Effects of serum starvation and vascular endothelial growth factor stimulation on the expression of Notch signalling pathway components ...