A posterior cruciate ligament (PCL) injury is a tear or sprain of the PCL, a ligament that crosses the back of your knee. Ligaments are tough bands of tissue that connect bones.

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San Francisco 49ers head coach Kyle Shanahan told reporters after Sunday night's game that McCaffrey suffered a PCL injury during the Niners' 35-10 loss to the Buffalo Bills.

Rothenberg said PCL injuries are often linked with other knee ligament tears. “The way that he tore his is one of the ways you can get an isolated tear of the PCL,” he said.

#49ers RB Christian McCaffrey (knee) is going on IR with a PCL injury. He will be out "at least 6 weeks" per, Kyle Shanahan. — Clayton Holloway (@HollowayNFLN) December 2, 2024.