Mice bearing the PDGF-Rα-GFP construct were described (13). Production of green-fluorescent protein (GFP) is controlled by the endogenous pdgf-rα promoter. GFP expression in PDGF-Rα-GFP mice ...

PDGF overproduction in rod photoreceptors under the regulation of the rhodopsin promoter causes neovascularization and retinal detachments in mice. [38, 68–70] The intravitreal injection of a ...

(b) Transactivation of the myogenin promoter (left panel) and of thymidine kinase (TK) promoter containing two tandem copies of PDGF α R P3 regulatory element (TAATCCCATTA, right panel) by WT and ...

Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and li ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted from skeletal muscle ...

Growth factor essential to epicardial cell function: Platelet derived growth factor (PDGF) plays role in heart regeneration Date: October 5, 2010 Source: Children's Hospital Los Angeles Summary ...

Scientists from Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted from skeletal muscle cells and helps ...

Ophthotech has seen its share price decimated after it announced over the weekend that its big hope, and what much of its financing has been centered around in recent years, failed to help wet AMD ...

FRANKLIN, Tenn., March 31, 2025--Lynch Regenerative Medicine, LLC., (LRM) announced today that it has acquired exclusive rights to REGRANEX® gel and recombinant purified platelet-derived growth factor ...

PDGF levels were depressed more in advanced AMD patients, which suggested an involvement of PDGF in AMD that warrants further investigation. [83] ...