Peripheral T-cell lymphomas not otherwise specified (PTCL/NOS) are very aggressive tumors characterized by consistent aberrant expression of platelet-derived growth factor receptor alpha (PDGFRA).

The temporal trajectory of platelet-derived growth factor (PDGF)-β receptor activation within the dorsocaudal brainstem parallels that of the mild hypoxic ventilatory depression (HVD) seen in ...

After their synthesis from four distinct genes, 52 the platelet-derived growth factor isoforms become activated by either intracellular or ... Ang-2, SDR-1 and the VEGF and PDGF receptors. ...

Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

On October 19, 2022, a new research paper was published in Oncotarget, entitled, “Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed ...

Scleroderma (systemic sclerosis) is characterized by the deposition and accumulation of excessive amounts of collagen and extracellular-matrix molecules, the dysfunction of microvascular endothelia ...

CDP860 is an engineered Fab' fragment-polyethylene glycol conjugate, which binds to and blocks the activity of the beta-subunit of the platelet-derived growth factor receptor (PDGFR-β).Studies in ...

This gene encodes a platelet derived growth factor ... (drugs that bind to receptors) for blocking PDGF signaling have been considered even more effective than the single VEGF treatment and are ...