The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

When the MAPK pathway is blocked, the cancer cells activate an alternative survival route, the phosphoinositide 3-kinase (PI3K) pathway. Attempts to block both pathways simultaneously have been ...

1 now present evidence that this extracellular electric field is the driving force in wound healing, and they uncover signaling pathways that ... phosphoinositide 3-kinase (PI3K) enzymes.

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K ... RAF kinase-driven ERK activation. The combination of Hsp90 inhibitors with RAF or MEK ...