Edmund Pezalla, MD, MPH, spoke with Physician’s Weekly about findings that show proton pump inhibitors may not increase risk ...

Data on rare, less frequent alleles can be found at [101]. CYP2C19-mediated interactions Ticlopidine ↑ PPI effect Inhibition of omeprazole 5'-hydroxylation, decreased elimination Increased ...

Proton pump inhibitors (PPIs) are a class of very effective and generally safe medicines used to treat heartburn, gastroesophageal reflux disease (GERD), and gastric ulcers.But not everyone who ...

Figure 1: Examples of small-molecule inhibitors of PPI targets. The ideal small-molecule drug target has a structure that falls into a class known to be 'druggable' and has well-understood biology ...

Koivunen et al. (pp. 749 and 768) describe the use of phage panning to isolate a cyclic peptide that selectively targets MMPs most closely associated with metastatic potential, and homes to ...

Cyclic peptides, which combine characteristics of both small molecules and proteins, have emerged as significant molecules ...

The study objective was to evaluate the association of proton pump inhibitors (PPIs) and community-acquired pneumonia (CAP). The design was a meta-analysis of nine case–controlled and cohort ...

Through this partnership, PRISM BioLab's proprietary small molecule peptide-mimetic PepMetics technology ... to discover orally available small molecule inhibitors of protein-protein interaction (PPI) ...

Co. Ltd. ("PRISM BioLab"), a leading discovery and development biotechnology company designing small molecule inhibitors of protein-protein interaction (PPI) targets, today announced that it has ...