The Ca 2+ levels, released by agonist-induced activity of phospholipase C, determine which contractile pathway is activated. In the following subsections we discuss in some detail some of the ...

Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of ...

Phospholipase C signaling and calcium influx. ... While several pathways can govern the generation of Ca 2+ signals, the phospholipase C pathway is possibly the most common.

Because M119 blocked phospholipase C and previous studies had suggested that phospholipase C blunts morphine’s pain relief, the researchers tested M119’s effect on the morphine-triggered pathway.

Phosphoinositide-phospholipase C (PI-PLC) enzymes are important players of the signal transduction pathways. 14 Two key molecules are PI-PLCγ1, mapped on chromosome 20q, 15 and PI-PLCβ1, localized on ...