Using this model, they uncovered the molecular mechanisms behind the "renal counterbalance" phenomenon, a process where the ...

Immunofluorescence demonstrated a failure of GLUT4-rich vesicles to reach the plasma membrane of the podocyte (Fig. 6 A) and a loss of insulin-induced tritiated glucose uptake (Fig. 6 B).

The glomerular podocyte is an archetypal example of such specialization, with a complex cytoskeleton underlying its delicate architectural features.

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

Protection of podocytes will be of paramount importance in preventing the development and progression of diabetic nephropathy.

Stage 5 chronic kidney disease, which heralds end-stage renal disease (ESRD) and the need for dialysis or transplantation, is a major and rapidly increasing socioeconomic burden worldwide. In 2011, ...

SAN DIEGO, June 11, 2025--Travere Therapeutics today announced that the Company will present three abstracts at the upcoming International Podocyte Conference.

To study the cellular and molecular mechanisms responsible for glomerular injury and podocyte loss and design therapeutics strategies targeted to the glomerulus, we must develop human physiologically ...

The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function.

Murine Podocyte Cell Line The conditionally immortalised murine podocyte cell line allows an in vitro process of maturation analogous to the development and maturation of podocytes in vivo. This cell ...

Purespring Therapeutics has become the first company to successfully treat kidney disease models by directly targeting the podocyte – a specialised cell implicated in approximately 60% of renal ...