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The primary causes of hereditary proteinuria syndromes are insults to the filtration barrier in the glomeruli of the kidney cortex (Figure 1A and Figure 1B).This barrier has three layers: the ...
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are ...
They have discovered that enzymatic processing of protein called dynamin can cause breakdown of a critical filtering structure called a podocyte, allowing protein to leak out of the bloodstream.
"The case highlights a critical, albeit rare, side effect of lenvatinib in the treatment of VHL syndrome, pointing to the necessity of individualized treatment strategies, vigilant monitoring, and ...
A novel glomerulopathy model demonstrates renal counterbalance via local angiotensin II regulation - ...
Podocyte Injury Comes of Age in Diabetic Nephropathy. Gunter Wolf; Sheldon Chen; ... the genesis of proteinuria in diabetes is not readily explained by the associated mesangial matrix expansion.
Using this model, they uncovered the molecular mechanisms behind the "renal counterbalance" phenomenon, a process where the ...
Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.
Mean proteinuria declined by 61.9% at week 4 and by 68.9% at week 24. At some point during treatment, 58% of participants had complete remission of proteinuria to below 0.3 g per day, according to ...
Overview of the mechanisms of podocyte injury leading to diabetic nephropathy. Metabolic factors in the diabetic milieu (TGF-β, high glucose, glycated proteins, ROS, and ANG II) and hemodynamic ...
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