Rhomboid proteases are a promising target for new drugs. Now researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have uncovered a mechanism for regulating enzyme ...

HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units. Their efficacy ...

For this paper, researchers used cryo-electron microscopy snapshots of Craspase systems to explain how they cleave to target RNA and activate protease enzymes, which can break down protein.

By combining many different techniques, researchers have discovered that ITIH4 inhibits proteases in the innate immune system via an unknown mechanism.

The next steps would be to expand the study to more enzymes and microbes, he said. “Various other microbes have various other proteases that are quite abundant, and presumably will be releasing those ...

Protease inhibitors are antiviral drugs commonly used to treat HIV. Learn about how they work, how effective they are, and more.

Why do some people feel itchy after a mosquito bite or exposure to an allergen like dust or pollen, while others do not? A new study has pinpointed the reason for these differences, finding the ...

Study: Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, impairing variants replication in vitro and in vivo. Image Credit: Juan Gaertner/Shutterstock This news article was a review of a ...

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the ...

The new protease enzyme was designed to help beverage formulators overcome typical challenges when using whey protein hydrolysates. The protease enzyme eliminates the need for added ingredients to ...