p38 proteins control a spectrum of processes, and their dysregulation has been linked to various diseases, making them promising pharmacological targets for clinical use.

A research team led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Science has ...

According to the findings, deletion of GADD45A also caused substantial cardiac hypertrophy that negatively affected cardiac morphology and function in mice lacking this protein.

The hope is that manipulating the same proteins in humans may prevent pathologic cardiac problems such as hypertrophy and mechanical dysfunction.

Patients with chronic kidney dysfunction frequently develop thickening of the heart muscle, so-called left ventricular hypertrophy. This is particularly pronounced in patients who are in the late ...

However, further research is required to understand better the HFpEF cardiomyocyte signaling cascades, including the protein kinase G (PKG) and CaMKII pathways, and to increase therapeutic ...