p38 proteins control a spectrum of processes, and their dysregulation has been linked to various diseases, making them promising pharmacological targets for clinical use.

A research team led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Science has ...

Toronto, ON - Researchers have discovered an unexpected interaction of proteins that appear to control the size and function of the heart and have been able to genetically uncouple them, creating ...

The main mechanisms involved in pathological hypertrophy include inflammatory processes, fibrosis, mitochondrial dysfunction, dysregulation of calcium-handling proteins, metabolic alterations ...

More information: Katharina Dörr et al. Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis, Circulation Research (2021).DOI: 10.1161/CIRCRESAHA.120.318556 ...

Inhibiting Ca2+ or calmodulin-based protein kinase II (CaMKII) restored pathological APD alterations in female and male HFpEF mice, and empagliflozin treatment matched CaMKII inhibition effects.