Unlike with protein kinases, the current knowledge of protein phosphatase functions remains fragmentary. In a new study, a research team report global quantitative interactomics analysis covering ...

Ferreira-Halder was principal investigator for the Thematic Project "Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation", supported by ...

Among the protein phosphatases, PP1, PP2A, and calcineurin are expressed at high levels in the brain. This study revealed that PP1 and calcineurin have sleep-regulating functions.

Acid phosphatase, Alkaline phosphatase, Protein tyrosine phosphatase, Serine/threonine phosphatase: Phosphatase Inhibitor Cocktail III (-)-p-Bromotetramisole oxalate, Cantharidin, Calyculin A: ...

Thus, PTEN is a protein phosphatase for IRS1, and its antagonism by NEDD4 promotes signaling by IGF and insulin. Nature Structural & Molecular Biology ...

Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to ...

This strategy avoids the off-target effects of indiscriminately boosting phosphatase activity, or globally suppressing kinases, since these enzymes have many substrates. In initial studies, Wang and ...

Receptor protein tyrosine phosphatases are cell membrane-localized proteins. They are regulators of cell–cell contacts and are also considered likely to be tumor suppressors but how they ...