The brain initiated a rapid remyelination process, but its effectiveness varied based on the extent of damage. Mild demyelination led to substantial recovery, whereas moderate to severe damage ...

the dysregulation of which will result in remyelination impairment. In response to a demyelinating insult, the myelinated axons undergo demyelination (1), a process that generates myelin debris.

Nearly all patients in the open-label extension of VISIONARY-MS showed MRI evidence of neuronal repair and remyelination. A presenter said CNM-Au8 achieved “a heretofore unseen clinical benefit ...

thereby contributing to the remyelination process. Further investigation identified an intermediate population among astrocytes where key transcription factors such as SOX10 promoted their ...

Our research focuses on the understanding of myelin regeneration (remyelination) and its failure during multiple sclerosis (MS). We aim to reveal how oligodendrocyte progenitor cell function is ...

Electron micrographs of the lumbar spinal cord showed remyelination in EAE-induced, Lingo1-knockout mice, but demyelination in wild-type control mice. Next, the authors tested whether inhibition ...

Clene (CLNN) announced new evidence of remyelination and neuronal repair in MS participants following treatment with CNM-Au8 30 mg from analyses of the VISIONARY-MS Trial long-term open-label ...

Inhibition of an ESI1 target promotes oligodendrocyte myelin production in mice, as shown as a dense curtain of green strands. This small molecule shows early promise as a potential treatment for ...