Movement is a complex process governed by a network of neuronal circuits spread across multiple regions of the nervous system ...

Adenosine triphosphate (ATP) secreted from sensory neuron-interneuron crosstalk is key to the spreading of inflammation across joints, acting as a neurotransmitter and inflammation enhancer.

The interneuron and motor neuron activity bursts occurred in unison, confirming to the authors that the interneurons were stimulating the motor neurons. Between mSOD1 and non-transgenic preparations, ...

New research improves our understanding of how motor nerve cells (neurons) respond to motor neuron disease, which could help us identify new treatment options.

Scientists have discovered that adenosine triphosphate (ATP) secreted from sensory neuron-interneuron crosstalk is key to the spreading of inflammation across joints, acting as a neurotransmitter ...

More information: Rie Hasebe et al, ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons, Journal of Experimental Medicine (2022).