The lack of extracellular adenosine signaling in Cd73 −/− mice causes susceptibility to hypoxia-induced inflammation 24 and barrier dysfunction of the vasculature and the intestine. 25,26 The ...

Transmembrane signaling involves sensing and communicating with the extracellular environment. Part of the transmembrane signaling is a process known as autoproteolysis, which is key in different ...

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117 ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into ...