When a degenerative signal is activated, HDAC1 modifies a component of a molecular motor, which then drives a signaling agent down the axon to the neuron's cell body, killing it. The motor is ...

L2 motor neuron axons were stimulated with a single stimulus at 0.1 Hz or at 20 Hz to emulate the physiological range of neonatal motor neuron firing. The maximum CMAP amplitude (baseline-to-peak ...

Through this axon tracing, the scientists identified a gene mutation that caused motor axon misrouting. In this case, the motor neuron axons took detours and never connected properly to the muscles.