Experimental & Molecular Medicine - Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells.

Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation ...

For example, µ-opioid receptors typically only activate so-called “inhibitory” G-proteins, which have the opposite effect of the stimulatory G protein cascade. However, scientists aren’t sure what ...

Researchers have found an unexpected synergy between a T-cell stimulatory protein -- the ICOS ligand -- and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

Among the activity-promoting co-stimulatory proteins is CD58. When it binds to its receptor on an immune cell, the cell receives a stimulatory signal.

Many hormones bind G-protein-coupled receptors, which wind back and forth through the cell membrane seven times and can exert either stimulatory or inhibitory effects.

et al. Inhibition of γ ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells. Exp Mol Med 39 , 583–593 ...

To date, one soluble recombinant fusion protein, that selectively blocks the co-stimulatory signal mediated by the B7/CD28 pathway, has been cleared for marketing in the U.S. for the treatment of ...

Maynard and his team were recently published in PNAS for their study “ICOS ligand and IL-10 synergize to promote host–microbiota mutualism.” In the study, Maynard and his team, including first author ...

Compugen Ltd. CGEN announced today in vitro validation of a second product candidate based on Compugen-discovered novel members of the B7/CD28 co-stimulatory protein family. Proteins belonging to ...