Instead, ER stress promotes the extracellular hydrolysis of sphingomyelin (SM)—a type of lipid—into Cer through the secretion of acid sphingomyelinase (ASM), highlighting an indirect ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

These chemical signals are propagated from the cell surface to intracellular processes via sequential kinase signaling, arranged in modules that exhibit redundancy and cross talk. This signal ...

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments. A series of rodent experiments showed ...

Team manipulates intracellular signal transduction using optogenetic technology. Story by Science X staff • 2mo.

Extracellular CDNs can enter the cytosol through several pathways but how CDNs work from outside eukaryotic cells remains poorly understood. Here, we elucidate a mechanism of action on intestinal ...

Researchers discover central switch point in mitochondrial signaling chain under misfolding stress Date: July 28, 2023 ... at which intervals the concentrations of intracellular substances change, ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into ...

Instead, ER stress promotes the extracellular hydrolysis of sphingomyelin (SM)—a type of lipid—into Cer through the secretion of acid sphingomyelinase (ASM), highlighting an indirect ...

Circulating cytokines, hormones, and growth factors control all aspects of cell proliferation, differentiation, angiogenesis, apoptosis, and senescence. These chemical signals are propagated from the ...