The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

The degree of complexity and crossover within MAPK signaling, and also shifts in pathways such as nuclear ... and spleen tyrosine kinase (Syk) targets are closer to the cell surface, and seem ...