Cell adhesion molecules localized at synapses do more than provide a physical link between pre and post-synaptic cells. Dalva and colleagues review the evidence for the roles of these molecules in ...

the synapses. This involves a complex interplay of electrochemical processes that bridge the tiny gaps between a sending cell and a receiving cell. The underlying mechanism is well known: put simply, ...

Scientists provide promising new evidence that the 'planar cell polarity,' a powerful signaling pathway, is a widely used mechanism for the formation and maintenance of a large number of synapses.

This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The ...

Because leptin plays a role in GABAergic synaptogenesis, levels of the hormone during development could influence the formation of both inhibitory and excitatory synapses, as well as downstream ...

Researchers at Leipzig University’s Carl Ludwig Institute have discovered that in the cerebral cortex, synaptic signal ...

When the researchers knocked out the LRP4 gene in fruit flies, they saw a 40 percent loss of excitatory synaptic connections in the brain, but no such loss of inhibitory synapses, suggesting that ...

More specifically, the “glutamatergic” synapses are the prime “excitatory” synapse junctions that neurons use to activate each other and are known to have broad diversity in size and shape.

Increased levels of bioactive lipids produced naturally in the body, which affect excitatory transmission between brain cells, promote mental disorders. However, this mechanism can be rebalanced ...

What does the term synaptic pruning mean? ... A 2021 study refers to previous research that suggests people with ASD have an increased density of excitatory synapses in the brain.

Every time I read about the synapse, the all-important junction between two neurons, the cartoon above pops into my head. It shows the gist of how a synapse works: An electrical pulse enters the ...