Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of ...

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development.

MSK researchers have identified two signaling pathways that work together to spur the spread of lung cancer. Taking away one of those signals could help slow or stop metastasis, findings in animal ...

A tale of two signaling pathways: TGF-Beta and RAS On its own, TGF-beta—a type of signaling protein known as a cytokine—is not an ideal drug target.

Two new mouse models of uterine cancer reveal that the TGF-beta signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and oncogenesis of the endometrium ...

Transforming growth factor-β (TGF-β) signaling plays a vital role in regulating cell growth, differentiation, and development in a wide array of biological systems.

The USP15 protein has been identified as novel target for therapy against cancer progression, investigators report. In certain settings, the TGF-beta pathway can act as an oncogene, enhancing ...

Background: TGF-beta acts both as a tumor suppressor or tumor promoter depending upon cellular context and stage of tumor progression. TGF-β exerts its effects through the TGF-beta-R1/ R2 receptors ...

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...

A team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against uterine cancer by suppressing ...

"The TGF-beta signaling pathway regulates the development of many types of cancer, but it was not clear whether it also played a role in uterine cancer development," said corresponding author Dr ...