As presented by Calvin Harley, [12] of Geron Corp. in Menlo Park, California, GRN163, a specific oligonucleotide telomerase inhibitor, is being developed as an anticancer agent. GRN163 is an ...

The analysis of the involvement of crisis in tumorigenesis has been aided by genetically defined cancer-prone mice that lack telomerase activity. These mouse models have provided insights into the ...

Cells from the telomerase knockout mouse immortalize with ... of this difference between mice and men and its relationship to cancer. The evidence supporting the relevance of replicative ...

"Mutations that upregulate telomerase activity are common in all types of cancers," said Dr. Lue. "In order for cancer cells to proliferate indefinitely, they need to activate telomerase to ...

Telomerase is a ribonucleoprotein enzyme responsible for maintaining ... 8 The observed association between shorter telomeres and increased risk of cancer, cardiovascular disease, and ...

The debate continues as to whether telomerase's only function is to promote telomere extension. In recent years evidence has suggested that the enzyme promotes cancer development and might have roles ...

Their findings pave the way for new therapeutic approaches targeting telomerase, an enzyme implicated in cancer progression. Colorectal cancer, which affects the colon or rectum, is the third most ...