A new study from Weill Cornell Medicine provides insights into how cells maintain the tiny end caps of chromosomes as they ...

Then, during the next round of DNA replication, DNA polymerase and the DNA repair enzymes fill in the other strand. Thus, telomerase is able to both maintain and extend the length of telomeres.

What remained to be seen was how CST, and its associated enzyme Polα-primase, travels to telomere to facilitate C-strand ...

Cell aging has always been an important topic in biological research, and telomere shortening is one of the key issues in cell aging studies.

Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.

This experiment showed that the biochemical machinery involved in telomere replication had to be very broadly conserved, and opened the door to studies of telomere biochemistry and genetics in yeast ...

(C) ssDNA is also generated at telomeres and is a signal of telomere instability. A common feature in all of these structures is the presence of ssDNA, which causes ATR activation to promote RF ...

Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair. A number of projects in the lab address fundamental questions ...

Disruption of telomere maintenance is catastrophic for the cell, and telomere processes are linked to both cancer and aging. We are also studying viral replication in the picornavirus family and the ...

Second, we have shown that the Mre11 complex is situated at human telomeres via its association with the telomere ... such as DNA recombination and replication within the cell. This insight will help ...

Cell aging has always been an important topic in biological research, and telomere shortening is one of the key issues in cell aging studies. Telomeres are special DNA sequences located at the ...