In 2010, there were 142,570 estimated new cases of colorectal cancer that led to an estimated 51,370 deaths, making it the third-leading cause of cancer death among men and women. Of the 142,570 ...

Thymidylate Synthase Expression in Colorectal Cancer: A Prognostic and Predictive Marker of Benefit From Adjuvant Fluorouracil-Based Chemotherapy. JCO 20 , 1721-1728 (2002). DOI: ...

Although a high level of thymidylate synthase (TS) expression in malignant tumours has been suggested to be related to a reduced sensitivity to the antifolate drug pemetrexed, no direct evidence ...

Fluorouracil blocks thymidylate synthase. Methotrexate blocks dihydrofolate reductase. Drugs cause megaloblastic anemia by impairing the cellular availability or use of folic acid or vitamin B 12.

Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries.

Doctors often use chemotherapy to treat NSCLC. Pemetrexed and cisplatin are drugs that may be used. Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to ...

Polyglutamated MTX also inhibits thymidylate synthetase (TYMS), which converts deoxyuridylate to deoxythymidylate in the de novo pyrimidine biosynthetic pathway.

Breast Cancer Consensus Meetings: Vive la Difference? PURPOSE: We studied the prognostic value of thymidylate synthase (TS) expression in primary colorectal cancer (CRC) and the role of TS expression ...